Suppression of the FOXM1 transcriptional program via novel small molecule inhibition

The transcription factor FOXM1 binds to sequence-specific motifs on DNA (C/TAAACA) through its DNA binding domain (DBD), and activates proliferation- and differentiation-associated genes. Aberrant overexpression of FOXM1 is a key feature in oncogenesis and progression of many human cancers. Here — f...

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Detalles Bibliográficos
Autores principales: Gormally, Michael V., Dexheimer, Thomas S., Marsico, Giovanni, Sanders, Deborah A., Lowe, Christopher, Matak-Vinkovi, Dijana, Michael, Sam, Jadhav, Ajit, Rai, Ganesha, Maloney, David J., Simeonov, Anton, Balasubramanian, Shankar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258842/
https://www.ncbi.nlm.nih.gov/pubmed/25387393
http://dx.doi.org/10.1038/ncomms6165

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258842/
https://www.ncbi.nlm.nih.gov/pubmed/25387393
http://dx.doi.org/10.1038/ncomms6165

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