Reconstitution of active human core Mediator complex reveals a pivotal role of the MED14 subunit

The evolutionarily conserved Mediator complex is a critical coactivator for RNA polymerase II (Pol II)-mediated transcription. Here, we report the reconstitution of a functional 15-subunit human core Mediator complex and its characterization by functional assays and chemical cross-linking coupled to...

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Detalles Bibliográficos
Autores principales: Cevher, Murat A., Shi, Yi, Li, Dan, Chait, Brian T., Malik, Sohail, Roeder, Robert G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259101/
https://www.ncbi.nlm.nih.gov/pubmed/25383669
http://dx.doi.org/10.1038/nsmb.2914

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259101/
https://www.ncbi.nlm.nih.gov/pubmed/25383669
http://dx.doi.org/10.1038/nsmb.2914

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