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Reconstitution of active human core Mediator complex reveals a pivotal role of the MED14 subunit

The evolutionarily conserved Mediator complex is a critical coactivator for RNA polymerase II (Pol II)-mediated transcription. Here, we report the reconstitution of a functional 15-subunit human core Mediator complex and its characterization by functional assays and chemical cross-linking coupled to...

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Detalles Bibliográficos
Autores principales:	Cevher, Murat A., Shi, Yi, Li, Dan, Chait, Brian T., Malik, Sohail, Roeder, Robert G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259101/ https://www.ncbi.nlm.nih.gov/pubmed/25383669 http://dx.doi.org/10.1038/nsmb.2914

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