U12, a UDCA Derivative, Acts as an Anti-Hepatoma Drug Lead and Inhibits the mTOR/S6K1 and Cyclin/CDK Complex Pathways

U12, one of 20 derivatives synthesized from ursodeoxycholic acid (UDCA), has been found to have anticancer effects in liver cancer cell lines (SMMC-7721 and HepG2) and to protect normal liver cells from deoxycholic acid (DCA) damage (QSG-7701). Its anticancer mechanism was investigated using compute...

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Detalles Bibliográficos
Autores principales: Xu, Yang, Luo, Qiang, Lin, Ting, Zeng, Zhiping, Wang, Guanghui, Zeng, Dequan, Ding, Rong, Sun, Cuiling, Zhang, Xiao-kun, Chen, Haifeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259312/
https://www.ncbi.nlm.nih.gov/pubmed/25486097
http://dx.doi.org/10.1371/journal.pone.0113479

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259312/
https://www.ncbi.nlm.nih.gov/pubmed/25486097
http://dx.doi.org/10.1371/journal.pone.0113479

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