Cargando…

U12, a UDCA Derivative, Acts as an Anti-Hepatoma Drug Lead and Inhibits the mTOR/S6K1 and Cyclin/CDK Complex Pathways

U12, one of 20 derivatives synthesized from ursodeoxycholic acid (UDCA), has been found to have anticancer effects in liver cancer cell lines (SMMC-7721 and HepG2) and to protect normal liver cells from deoxycholic acid (DCA) damage (QSG-7701). Its anticancer mechanism was investigated using compute...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Yang, Luo, Qiang, Lin, Ting, Zeng, Zhiping, Wang, Guanghui, Zeng, Dequan, Ding, Rong, Sun, Cuiling, Zhang, Xiao-kun, Chen, Haifeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259312/ https://www.ncbi.nlm.nih.gov/pubmed/25486097 http://dx.doi.org/10.1371/journal.pone.0113479

Ejemplares similares

Synthesis and Anti-Hepatoma Activities of U12 Derivatives Arresting G0/G1 Phase and Inducing Apoptosis by PI3K/AKT/mTOR Pathway
por: Yang, Renjing, et al.
Publicado: (2022)

Differential effects of norUDCA and UDCA in obstructive cholestasis in mice
por: Fickert, Peter, et al.
Publicado: (2013)

Glyceric Prodrug of Ursodeoxycholic Acid (UDCA): Novozym 435-Catalyzed Synthesis of UDCA-Monoglyceride
por: Zappaterra, Federico, et al.
Publicado: (2021)

Integrin α2 and β1 Cross-Communication with mTOR/AKT and the CDK-Cyclin Axis in Hepatocellular Carcinoma Cells
por: Juratli, Mazen A., et al.
Publicado: (2022)

Allyl-, Butyl- and Phenylethyl-Isothiocyanate Modulate Akt–mTOR and Cyclin–CDK Signaling in Gemcitabine- and Cisplatin-Resistant Bladder Cancer Cell Lines
por: Rutz, Jochen, et al.
Publicado: (2022)

A new meroterpenoid functions as an anti-tumor agent in hepatoma cells by downregulating mTOR activation and inhibiting EMT
por: Wan, Haoqiang, et al.
Publicado: (2018)

Inhibition of the CDK2 and Cyclin A complex leads to autophagic degradation of CDK2 in cancer cells
por: Zhang, Jiawei, et al.
Publicado: (2022)

mTOR Pathway and mTOR Inhibitors in Head and Neck Cancer
por: Gao, Wei, et al.
Publicado: (2012)

Cyclin K goes with Cdk12 and Cdk13
por: Kohoutek, Jiri, et al.
Publicado: (2012)

UDCA in UC: A true disease modifier or symptoms reliever?
por: Sulais, Eman Al
Publicado: (2021)

Molecular docking analysis of piperine with CDK2,CDK4,Cyclin D and Cyclin T proteins
por: Rekha, Umapathy Vidhya, et al.
Publicado: (2020)

Cyclin-dependent kinase inhibitor 2B gene is associated with the sensitivity of hepatoma cells to Sorafenib
por: Weng, Xie, et al.
Publicado: (2019)

Alpha-fetoprotein activates AKT/mTOR signaling to promote CXCR4 expression and migration of hepatoma cells
por: Zhu, Mingyue, et al.
Publicado: (2015)

The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K
por: Słabicki, Mikołaj, et al.
Publicado: (2020)

Latest development in the synthesis of ursodeoxycholic acid (UDCA): a critical review
por: Tonin, Fabio, et al.
Publicado: (2018)

Repurposing UDCA, an FXR Inhibitor, to Prevent SARS-Cov-2 Infection
por: Prayitno, Khairunnadiya, et al.
Publicado: (2023)

UDCA, a novel strategy for preventing SARS-CoV-2 infection via FXR-mediated ACE2 downregulation: UDCA and SARS-CoV-2 infection
por: Chen, Mengjiao, et al.
Publicado: (2023)

Nuclear Import of Cdk/Cyclin Complexes: Identification of Distinct Mechanisms for Import of Cdk2/Cyclin E and Cdc2/Cyclin B1
por: Moore, Jonathan D., et al.
Publicado: (1999)

Cyclin B Translation Depends on mTOR Activity after Fertilization in Sea Urchin Embryos
por: Chassé, Héloïse, et al.
Publicado: (2016)

CDK1 substitutes for mTOR kinase to activate mitotic cap-dependent protein translation
por: Shuda, Masahiro, et al.
Publicado: (2015)

Saikosaponin-d increases radiation-induced apoptosis of hepatoma cells by promoting autophagy via inhibiting mTOR phosphorylation
por: Wang, Baofeng, et al.
Publicado: (2021)

Cell cycle progression mechanisms: slower cyclin-D/CDK4 activation and faster cyclin-E/CDK2
por: Zhang, Wengang, et al.
Publicado: (2023)

Pretreatment with Ursodeoxycholic Acid (UDCA) as a Novel Pharmacological Intervention in Hepatobiliary Scintigraphy
por: Jeong, Hwan-Jeong, et al.
Publicado: (2005)

Bufadienolides from Venenum Bufonis Inhibit mTOR-Mediated Cyclin D1 and Retinoblastoma Protein Leading to Arrest of Cell Cycle in Cancer Cells
por: Chang, Huamei, et al.
Publicado: (2018)

Activation of mTOR: a culprit of Alzheimer’s disease?
por: Cai, Zhiyou, et al.
Publicado: (2015)

Break CDK2/Cyclin E1 Interface Allosterically with Small Peptides
por: Chen, Hao, et al.
Publicado: (2014)

Comparison of deregulated expression of cyclin D1 and cyclin E with that of cyclin-dependent kinase 4 (CDK4) and CDK2 in human oesophageal squamous cell carcinoma
por: Matsumoto, M, et al.
Publicado: (1999)

Waking Action of Ursodeoxycholic Acid (UDCA) Involves Histamine and GABA(A) Receptor Block
por: Yanovsky, Yevgenij, et al.
Publicado: (2012)

External Validation of UDCA Response Score in Slovak and Croatian Patients with Primary Biliary Cholangitis
por: Gazda, Jakub, et al.
Publicado: (2021)

Gut Microbial Profile Changes in Patients with Gallbladder Stones after UDCA/CDCA Treatment
por: Lee, Jungnam, et al.
Publicado: (2023)

Cyclin B/CDK1 and Cyclin A/CDK2 phosphorylate DENR to promote mitotic protein translation and faithful cell division
por: Clemm von Hohenberg, Katharina, et al.
Publicado: (2022)

Phylogenetic analysis of CDK and cyclin proteins in premetazoan lineages
por: Cao, Lihuan, et al.
Publicado: (2014)

Structural insights into the functional diversity of the CDK–cyclin family
por: Wood, Daniel J., et al.
Publicado: (2018)

The awakening of the CDK10/Cyclin M protein kinase
por: Guen, Vincent J., et al.
Publicado: (2017)

Lineage specific composition of cyclin D–CDK4/CDK6–p27 complexes reveals distinct functions of CDK4, CDK6 and individual D‐type cyclins in differentiating cells of embryonic origin
por: Bryja, V., et al.
Publicado: (2008)

Alisol B 23-acetate-induced HepG2 hepatoma cell death through mTOR signaling-initiated G(1) cell cycle arrest and apoptosis: A quantitative proteomic study
por: Xia, Ji, et al.
Publicado: (2019)

Ursodeoxycholic Acid (UDCA) Exerts Anti-Atherogenic Effects by Inhibiting RAGE Signaling in Diabetic Atherosclerosis
por: Chung, Jihwa, et al.
Publicado: (2016)

Myelination and mTOR
por: Figlia, Gianluca, et al.
Publicado: (2017)

TOX Acts as a Tumor Suppressor by Inhibiting mTOR Signaling in Colorectal Cancer
por: Yang, Mengdi, et al.
Publicado: (2021)

mTOR inhibition acts as an unexpected checkpoint in p53-mediated tumor suppression
por: Kon, Ning, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_5hj160r6244u5k3c7qj7tpqpeu