Increased N-Glycosylation Efficiency by Generation of an Aromatic Sequon on N135 of Antithrombin

The inefficient glycosylation of consensus sequence on N135 in antithrombin explains the two glycoforms of this key anticoagulant serpin found in plasma: α and β, with four and three N-glycans, respectively. The lack of this N-glycan increases the heparin affinity of the β-glycoform. Recent studies...

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Detalles Bibliográficos
Autores principales: Águila, Sonia, Martínez-Martínez, Irene, Dichiara, Gilda, Gutiérrez-Gallego, Ricardo, Navarro-Fernández, José, Vicente, Vicente, Corral, Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259341/
https://www.ncbi.nlm.nih.gov/pubmed/25485983
http://dx.doi.org/10.1371/journal.pone.0114454

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259341/
https://www.ncbi.nlm.nih.gov/pubmed/25485983
http://dx.doi.org/10.1371/journal.pone.0114454

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