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Increased N-Glycosylation Efficiency by Generation of an Aromatic Sequon on N135 of Antithrombin
The inefficient glycosylation of consensus sequence on N135 in antithrombin explains the two glycoforms of this key anticoagulant serpin found in plasma: α and β, with four and three N-glycans, respectively. The lack of this N-glycan increases the heparin affinity of the β-glycoform. Recent studies...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259341/ https://www.ncbi.nlm.nih.gov/pubmed/25485983 http://dx.doi.org/10.1371/journal.pone.0114454 |