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Design of DNA Pooling to Allow Incorporation of Covariates in Rare Variants Analysis

BACKGROUND: Rapid advances in next-generation sequencing technologies facilitate genetic association studies of an increasingly wide array of rare variants. To capture the rare or less common variants, a large number of individuals will be needed. However, the cost of a large scale study using whole...

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Detalles Bibliográficos
Autores principales: Guan, Weihua, Li, Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259344/
https://www.ncbi.nlm.nih.gov/pubmed/25485788
http://dx.doi.org/10.1371/journal.pone.0114523