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CRISPR Reveals a Distal Super-Enhancer Required for Sox2 Expression in Mouse Embryonic Stem Cells

The pluripotency of embryonic stem cells (ESCs) is maintained by a small group of master transcription factors including Oct4, Sox2 and Nanog. These core factors form a regulatory circuit controlling the transcription of a number of pluripotency factors including themselves. Although previous studie...

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Detalles Bibliográficos
Autores principales:	Li, Yan, Rivera, Chloe M., Ishii, Haruhiko, Jin, Fulai, Selvaraj, Siddarth, Lee, Ah Young, Dixon, Jesse R., Ren, Bing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259346/ https://www.ncbi.nlm.nih.gov/pubmed/25486255 http://dx.doi.org/10.1371/journal.pone.0114485

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