Identification of the Interactors of Human Nibrin (NBN) and of Its 26 kDa and 70 kDa Fragments Arising from the NBN 657del5 Founder Mutation

Nibrin (also named NBN or NBS1) is a component of the MRE11/RAD50/NBN complex, which is involved in early steps of DNA double strand breaks sensing and repair. Mutations within the NBN gene are responsible for the Nijmegen breakage syndrome (NBS). The 90% of NBS patients are homozygous for the 657de...

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Detalles Bibliográficos
Autores principales: Cilli, Domenica, Mirasole, Cristiana, Pennisi, Rosa, Pallotta, Valeria, D'Alessandro, Angelo, Antoccia, Antonio, Zolla, Lello, Ascenzi, Paolo, di Masi, Alessandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259352/
https://www.ncbi.nlm.nih.gov/pubmed/25485873
http://dx.doi.org/10.1371/journal.pone.0114651

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259352/
https://www.ncbi.nlm.nih.gov/pubmed/25485873
http://dx.doi.org/10.1371/journal.pone.0114651

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