Activity of the novel mTOR inhibitor Torin-2 in B-precursor acute lymphoblastic leukemia and its therapeutic potential to prevent Akt reactivation

The PI3K/Akt/mTOR signaling cascade is a key regulatory pathway controlling cell growth and survival, and its dysregulation is a reported feature of B-precursor acute lymphoblastic leukemia (B-pre ALL). Torin-2 is a novel, second-generation ATP-competitive inhibitor that is potent and selective for...

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Detalles Bibliográficos
Autores principales: Simioni, Carolina, Cani, Alice, Martelli, Alberto M., Zauli, Giorgio, Tabellini, Giovanna, McCubrey, James, Capitani, Silvano, Neri, Luca M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259403/
https://www.ncbi.nlm.nih.gov/pubmed/25296981

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259403/
https://www.ncbi.nlm.nih.gov/pubmed/25296981

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