Inhibition of SphK1 reduces radiation-induced migration and enhances sensitivity to cetuximab treatment by affecting the EGFR/SphK1 crosstalk

SphK1 is known to play a role in tumor progression, resistance to radiochemotherapy, and migration patterns. As the overall survival rates of squamous cell carcinoma of the head and neck (HNSCC) remain poor due to limitations in surgery and irradiation and chemotherapy resistance, SphK1 is an import...

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Detalles Bibliográficos
Autores principales: Schiefler, Carlotta, Piontek, Guido, Doescher, Johannes, Schuettler, Dominik, Mißlbeck, Martin, Rudelius, Martina, Haug, Anna, Reiter, Rudolf, Brockhoff, Gero, Pickhard, Anja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259444/
https://www.ncbi.nlm.nih.gov/pubmed/25245676

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259444/
https://www.ncbi.nlm.nih.gov/pubmed/25245676

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