Mutational profiles in triple-negative breast cancer defined by ultradeep multigene sequencing show high rates of PI3K pathway alterations and clinically relevant entity subgroup specific differences

Mutational profiling of triple-negative breast cancer (TNBC) by whole exome sequencing (WES) yielded a landscape of genomic alterations in this tumor entity. However, the clinical significance of these findings remains enigmatic. Further, integration of WES in routine diagnostics using formalin-fixe...

Descripción completa

Detalles Bibliográficos
Autores principales: Kriegsmann, Mark, Endris, Volker, Wolf, Thomas, Pfarr, Nicole, Stenzinger, Albrecht, Loibl, Sibylle, Denkert, Carsten, Schneeweiss, Andreas, Budczies, Jan, Sinn, Peter, Weichert, Wilko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259450/
https://www.ncbi.nlm.nih.gov/pubmed/25296970

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259450/
https://www.ncbi.nlm.nih.gov/pubmed/25296970

Ejemplares similares