Specificity Rendering ‘Hot-Spots’ for Aurora Kinase Inhibitor Design: The Role of Non-Covalent Interactions and Conformational Transitions

The present study examines the conformational transitions occurring among the major structural motifs of Aurora kinase (AK) concomitant with the DFG-flip and deciphers the role of non-covalent interactions in rendering specificity. Multiple sequence alignment, docking and structural analysis of a re...

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Detalles Bibliográficos
Autores principales: Badrinarayan, Preethi, Sastry, G. Narahari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259475/
https://www.ncbi.nlm.nih.gov/pubmed/25485544
http://dx.doi.org/10.1371/journal.pone.0113773

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259475/
https://www.ncbi.nlm.nih.gov/pubmed/25485544
http://dx.doi.org/10.1371/journal.pone.0113773

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