SOXC proteins amplify canonical WNT signaling to secure nonchondrocytic fates in skeletogenesis

Canonical WNT signaling stabilizes β-catenin to determine cell fate in many processes from development onwards. One of its main roles in skeletogenesis is to antagonize the chondrogenic transcription factor SOX9. We here identify the SOXC proteins as potent amplifiers of this pathway. The SOXC genes...

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Detalles Bibliográficos
Autores principales: Bhattaram, Pallavi, Penzo-Méndez, Alfredo, Kato, Kenji, Bandyopadhyay, Kaustav, Gadi, Abhilash, Taketo, Makoto M., Lefebvre, Véronique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259807/
https://www.ncbi.nlm.nih.gov/pubmed/25452386
http://dx.doi.org/10.1083/jcb.201405098

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259807/
https://www.ncbi.nlm.nih.gov/pubmed/25452386
http://dx.doi.org/10.1083/jcb.201405098

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