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Systematic Analysis of New Drug Indications by Drug-Gene-Disease Coherent Subnetworks
Drug targets and disease genes may work as driver factors at the transcriptional level, which propagate signals through gene regulatory network and cause the downstream genes' differential expression. How to analyze transcriptional response data to identify meaningful gene modules shared by bot...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259999/ https://www.ncbi.nlm.nih.gov/pubmed/25390685 http://dx.doi.org/10.1038/psp.2014.44 |