Physiologically Based Pharmacokinetic Modeling and Simulation in Pediatric Drug Development

Increased regulatory demands for pediatric drug development research have fostered interest in the use of modeling and simulation among industry and academia. Physiologically based pharmacokinetic (PBPK) modeling offers a unique modality to incorporate multiple levels of information to estimate age-...

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Detalles Bibliográficos
Autores principales: Maharaj, A R, Edginton, A N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Tutorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260000/
https://www.ncbi.nlm.nih.gov/pubmed/25353188
http://dx.doi.org/10.1038/psp.2014.45
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author Maharaj, A R
Edginton, A N
author_facet Maharaj, A R
Edginton, A N
author_sort Maharaj, A R
collection PubMed
description Increased regulatory demands for pediatric drug development research have fostered interest in the use of modeling and simulation among industry and academia. Physiologically based pharmacokinetic (PBPK) modeling offers a unique modality to incorporate multiple levels of information to estimate age-specific pharmacokinetics. This tutorial will serve to provide the reader with a basic understanding of the procedural steps to developing a pediatric PBPK model and facilitate a discussion of the advantages and limitations of this modeling technique.
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spelling pubmed-42600002014-12-12 Physiologically Based Pharmacokinetic Modeling and Simulation in Pediatric Drug Development Maharaj, A R Edginton, A N CPT Pharmacometrics Syst Pharmacol Tutorial Increased regulatory demands for pediatric drug development research have fostered interest in the use of modeling and simulation among industry and academia. Physiologically based pharmacokinetic (PBPK) modeling offers a unique modality to incorporate multiple levels of information to estimate age-specific pharmacokinetics. This tutorial will serve to provide the reader with a basic understanding of the procedural steps to developing a pediatric PBPK model and facilitate a discussion of the advantages and limitations of this modeling technique. Nature Publishing Group 2014-11 2014-11-19 /pmc/articles/PMC4260000/ /pubmed/25353188 http://dx.doi.org/10.1038/psp.2014.45 Text en Copyright © 2014 American Society for Clinical Pharmacology and Therapeutics http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
spellingShingle Tutorial
Maharaj, A R
Edginton, A N
Physiologically Based Pharmacokinetic Modeling and Simulation in Pediatric Drug Development
title Physiologically Based Pharmacokinetic Modeling and Simulation in Pediatric Drug Development
title_full Physiologically Based Pharmacokinetic Modeling and Simulation in Pediatric Drug Development
title_fullStr Physiologically Based Pharmacokinetic Modeling and Simulation in Pediatric Drug Development
title_full_unstemmed Physiologically Based Pharmacokinetic Modeling and Simulation in Pediatric Drug Development
title_short Physiologically Based Pharmacokinetic Modeling and Simulation in Pediatric Drug Development
title_sort physiologically based pharmacokinetic modeling and simulation in pediatric drug development
topic Tutorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260000/
https://www.ncbi.nlm.nih.gov/pubmed/25353188
http://dx.doi.org/10.1038/psp.2014.45
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