FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis

The role of Fat Mass and Obesity-associated protein (FTO) and its substrate N6-methyladenosine (m(6)A) in mRNA processing and adipogenesis remains largely unknown. We show that FTO expression and m(6)A levels are inversely correlated during adipogenesis. FTO depletion blocks differentiation and only...

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Detalles Bibliográficos
Autores principales: Zhao, Xu, Yang, Ying, Sun, Bao-Fa, Shi, Yue, Yang, Xin, Xiao, Wen, Hao, Ya-Juan, Ping, Xiao-Li, Chen, Yu-Sheng, Wang, Wen-Jia, Jin, Kang-Xuan, Wang, Xing, Huang, Chun-Min, Fu, Yu, Ge, Xiao-Meng, Song, Shu-Hui, Jeong, Hyun Seok, Yanagisawa, Hiroyuki, Niu, Yamei, Jia, Gui-Fang, Wu, Wei, Tong, Wei-Min, Okamoto, Akimitsu, He, Chuan, Danielsen, Jannie M Rendtlew, Wang, Xiu-Jie, Yang, Yun-Gui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260349/
https://www.ncbi.nlm.nih.gov/pubmed/25412662
http://dx.doi.org/10.1038/cr.2014.151

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260349/
https://www.ncbi.nlm.nih.gov/pubmed/25412662
http://dx.doi.org/10.1038/cr.2014.151

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