Bortezomib enhances cancer cell death by blocking the autophagic flux through stimulating ERK phosphorylation

The antitumor activity of an inhibitor of 26S proteasome bortezomib (Velcade) has been observed in various malignancies, including colon cancer, prostate cancer, breast cancer, and ovarian cancer. Bortezomib has been proposed to stimulate autophagy, but scientific observations did not always support...

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Detalles Bibliográficos
Autores principales: Kao, C, Chao, A, Tsai, C-L, Chuang, W-C, Huang, W-P, Chen, G-C, Lin, C-Y, Wang, T-H, Wang, H-S, Lai, C-H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260726/
https://www.ncbi.nlm.nih.gov/pubmed/25375375
http://dx.doi.org/10.1038/cddis.2014.468

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260726/
https://www.ncbi.nlm.nih.gov/pubmed/25375375
http://dx.doi.org/10.1038/cddis.2014.468

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