Role of extracellular calcium and mitochondrial oxygen species in psychosine-induced oligodendrocyte cell death

Globoid cell leukodystrophy (GLD) is a metabolic disease caused by mutations in the galactocerebrosidase (GALC) gene. GALC is a lysosomal enzyme whose function is to degrade galacto-lipids, including galactosyl-ceramide and galactosyl-sphingosine (psychosine, PSY). GALC loss of function causes progr...

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Detalles Bibliográficos
Autores principales: Voccoli, V, Tonazzini, I, Signore, G, Caleo, M, Cecchini, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260741/
https://www.ncbi.nlm.nih.gov/pubmed/25412308
http://dx.doi.org/10.1038/cddis.2014.483

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260741/
https://www.ncbi.nlm.nih.gov/pubmed/25412308
http://dx.doi.org/10.1038/cddis.2014.483

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