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Evolutionary triage governs fitness in driver and passenger mutations and suggests targeting never mutations
Genetic and epigenetic changes in cancer cells are typically divided into “drivers” and “passengers”. Drug development strategies target driver mutations, but inter- and intra-tumoral heterogeneity usually results in emergence of resistance. Here we model intratumoral evolution in the context of a f...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260773/ https://www.ncbi.nlm.nih.gov/pubmed/25407411 http://dx.doi.org/10.1038/ncomms6499 |