Combined Efficacy of Cediranib and Quinacrine in Glioma Is Enhanced by Hypoxia and Causally Linked to Autophagic Vacuole Accumulation

We have previously reported that the in vivo anti-glioma efficacy of the anti-angiogenic receptor tyrosine kinase inhibitor cediranib is substantially enhanced via combination with the late-stage autophagy inhibitor quinacrine. The current study investigates the role of hypoxia and autophagy in comb...

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Detalles Bibliográficos
Autores principales: Lobo, Merryl R., Wang, Xiaoyan, Gillespie, G. Yancey, Woltjer, Randall L., Pike, Martin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260788/
https://www.ncbi.nlm.nih.gov/pubmed/25490024
http://dx.doi.org/10.1371/journal.pone.0114110

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260788/
https://www.ncbi.nlm.nih.gov/pubmed/25490024
http://dx.doi.org/10.1371/journal.pone.0114110

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