Metabolic Signatures of Adiposity in Young Adults: Mendelian Randomization Analysis and Effects of Weight Change

BACKGROUND: Increased adiposity is linked with higher risk for cardiometabolic diseases. We aimed to determine to what extent elevated body mass index (BMI) within the normal weight range has causal effects on the detailed systemic metabolite profile in early adulthood. METHODS AND FINDINGS: We used...

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Detalles Bibliográficos
Autores principales: Würtz, Peter, Wang, Qin, Kangas, Antti J., Richmond, Rebecca C., Skarp, Joni, Tiainen, Mika, Tynkkynen, Tuulia, Soininen, Pasi, Havulinna, Aki S., Kaakinen, Marika, Viikari, Jorma S., Savolainen, Markku J., Kähönen, Mika, Lehtimäki, Terho, Männistö, Satu, Blankenberg, Stefan, Zeller, Tanja, Laitinen, Jaana, Pouta, Anneli, Mäntyselkä, Pekka, Vanhala, Mauno, Elliott, Paul, Pietiläinen, Kirsi H., Ripatti, Samuli, Salomaa, Veikko, Raitakari, Olli T., Järvelin, Marjo-Riitta, Smith, George Davey, Ala-Korpela, Mika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260795/
https://www.ncbi.nlm.nih.gov/pubmed/25490400
http://dx.doi.org/10.1371/journal.pmed.1001765

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260795/
https://www.ncbi.nlm.nih.gov/pubmed/25490400
http://dx.doi.org/10.1371/journal.pmed.1001765

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