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The Robustness of a Signaling Complex to Domain Rearrangements Facilitates Network Evolution
The rearrangement of protein domains is known to have key roles in the evolution of signaling networks and, consequently, is a major tool used to synthetically rewire networks. However, natural mutational events leading to the creation of proteins with novel domain combinations, such as in frame fus...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260825/ https://www.ncbi.nlm.nih.gov/pubmed/25490747 http://dx.doi.org/10.1371/journal.pbio.1002012 |