Computational Construction of Antibody–Drug Conjugates Using Surface Lysines as the Antibody Conjugation Site and a Non-cleavable Linker

Antibody–drug conjugates (ADCs) constitute a category of anticancer targeted therapy that has gathered great interest during the last few years because of their potential to kill cancer cells while causing significantly fewer side effects than traditional chemotherapy. In this paper, a process of co...

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Detalles Bibliográficos
Autores principales: Filntisi, Arianna, Vlachakis, Dimitrios, Matsopoulos, George K, Kossida, Sophia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260860/
https://www.ncbi.nlm.nih.gov/pubmed/25506200
http://dx.doi.org/10.4137/CIN.S19222
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author Filntisi, Arianna
Vlachakis, Dimitrios
Matsopoulos, George K
Kossida, Sophia
author_facet Filntisi, Arianna
Vlachakis, Dimitrios
Matsopoulos, George K
Kossida, Sophia
author_sort Filntisi, Arianna
collection PubMed
description Antibody–drug conjugates (ADCs) constitute a category of anticancer targeted therapy that has gathered great interest during the last few years because of their potential to kill cancer cells while causing significantly fewer side effects than traditional chemotherapy. In this paper, a process of computational construction of ADCs is described, using the surface lysines of an antibody and a non-covalent linker molecule, as well as a cytotoxic substance, as files in Protein Data Bank format. Also, aspects related to the function, properties, and development of ADCs are discussed.
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spelling pubmed-42608602014-12-12 Computational Construction of Antibody–Drug Conjugates Using Surface Lysines as the Antibody Conjugation Site and a Non-cleavable Linker Filntisi, Arianna Vlachakis, Dimitrios Matsopoulos, George K Kossida, Sophia Cancer Inform Original Research Antibody–drug conjugates (ADCs) constitute a category of anticancer targeted therapy that has gathered great interest during the last few years because of their potential to kill cancer cells while causing significantly fewer side effects than traditional chemotherapy. In this paper, a process of computational construction of ADCs is described, using the surface lysines of an antibody and a non-covalent linker molecule, as well as a cytotoxic substance, as files in Protein Data Bank format. Also, aspects related to the function, properties, and development of ADCs are discussed. Libertas Academica 2014-12-08 /pmc/articles/PMC4260860/ /pubmed/25506200 http://dx.doi.org/10.4137/CIN.S19222 Text en © 2014 the author(s), publisher and licensee Libertas Academica Ltd. This is an open-access article distributed under the terms of the Creative Commons CC-BY-NC 3.0 License.
spellingShingle Original Research
Filntisi, Arianna
Vlachakis, Dimitrios
Matsopoulos, George K
Kossida, Sophia
Computational Construction of Antibody–Drug Conjugates Using Surface Lysines as the Antibody Conjugation Site and a Non-cleavable Linker
title Computational Construction of Antibody–Drug Conjugates Using Surface Lysines as the Antibody Conjugation Site and a Non-cleavable Linker
title_full Computational Construction of Antibody–Drug Conjugates Using Surface Lysines as the Antibody Conjugation Site and a Non-cleavable Linker
title_fullStr Computational Construction of Antibody–Drug Conjugates Using Surface Lysines as the Antibody Conjugation Site and a Non-cleavable Linker
title_full_unstemmed Computational Construction of Antibody–Drug Conjugates Using Surface Lysines as the Antibody Conjugation Site and a Non-cleavable Linker
title_short Computational Construction of Antibody–Drug Conjugates Using Surface Lysines as the Antibody Conjugation Site and a Non-cleavable Linker
title_sort computational construction of antibody–drug conjugates using surface lysines as the antibody conjugation site and a non-cleavable linker
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260860/
https://www.ncbi.nlm.nih.gov/pubmed/25506200
http://dx.doi.org/10.4137/CIN.S19222
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