p53-Dependent Activation of microRNA-34a in Response to Etoposide-Induced DNA Damage in Osteosarcoma Cell Lines Not Impaired by Dominant Negative p53 Expression

Osteosarcoma (OS) is the most common primary malignant bone tumor and prevalently occurs in the second decade of life. Etoposide, a chemotherapeutic agent used in combined treatments of recurrent human OS, belongs to the topoisomerase inhibitor family and causes DNA breakage. In this study we evalua...

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Detalles Bibliográficos
Autores principales: Novello, Chiara, Pazzaglia, Laura, Conti, Amalia, Quattrini, Irene, Pollino, Serena, Perego, Paola, Picci, Piero, Benassi, Maria Serena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260944/
https://www.ncbi.nlm.nih.gov/pubmed/25490093
http://dx.doi.org/10.1371/journal.pone.0114757

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260944/
https://www.ncbi.nlm.nih.gov/pubmed/25490093
http://dx.doi.org/10.1371/journal.pone.0114757

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