Dynamic Conformations of Nucleophosmin (NPM1) at a Key Monomer-Monomer Interface Affect Oligomer Stability and Interactions with Granzyme B

Nucleophosmin (NPM1) is an abundant, nucleolar tumor antigen with important roles in cell proliferation and putative contributions to oncogenesis. Wild-type NPM1 forms pentameric oligomers through interactions at the amino-terminal core domain. A truncated form of NPM1 found in some hepatocellular c...

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Detalles Bibliográficos
Autores principales: Duan-Porter, Wei D., Woods, Virgil L., Maurer, Kimberly D., Li, Sheng, Rosen, Antony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260957/
https://www.ncbi.nlm.nih.gov/pubmed/25490769
http://dx.doi.org/10.1371/journal.pone.0115062

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260957/
https://www.ncbi.nlm.nih.gov/pubmed/25490769
http://dx.doi.org/10.1371/journal.pone.0115062

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