Cargando…

Dynamic Conformations of Nucleophosmin (NPM1) at a Key Monomer-Monomer Interface Affect Oligomer Stability and Interactions with Granzyme B

Nucleophosmin (NPM1) is an abundant, nucleolar tumor antigen with important roles in cell proliferation and putative contributions to oncogenesis. Wild-type NPM1 forms pentameric oligomers through interactions at the amino-terminal core domain. A truncated form of NPM1 found in some hepatocellular c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Duan-Porter, Wei D., Woods, Virgil L., Maurer, Kimberly D., Li, Sheng, Rosen, Antony
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260957/ https://www.ncbi.nlm.nih.gov/pubmed/25490769 http://dx.doi.org/10.1371/journal.pone.0115062

Ejemplares similares

Perturbation of the Monomer–Monomer Interfaces of the Benzoylformate Decarboxylase Tetramer
por: Andrews, Forest H., et al.
Publicado: (2014)

Monomer and Oligomer Transition of Zinc Phthalocyanine Is Key for Photobleaching in Photodynamic Therapy
por: Liu, Dafeng, et al.
Publicado: (2023)

Function of homo- and hetero-oligomers of human nucleoplasmin/nucleophosmin family proteins NPM1, NPM2 and NPM3 during sperm chromatin remodeling
por: Okuwaki, Mitsuru, et al.
Publicado: (2012)

Effects of microvirin monomers and oligomers on hepatitis C virus
por: Min, Yuan-Qin, et al.
Publicado: (2017)

Redesign of the monomer–monomer interface of Cre recombinase yields an obligate heterotetrameric complex
por: Zhang, Chi, et al.
Publicado: (2015)

Beta‐amyloid 1‐42 monomers, but not oligomers, produce PHF‐like conformation of Tau protein
por: Manassero, Giusi, et al.
Publicado: (2016)

Photocurable Coatings Based on Bio-Renewable Oligomers and Monomers
por: Bednarczyk, Paulina, et al.
Publicado: (2021)

Solo vs. Chorus: Monomers and Oligomers of Arrestin Proteins
por: Gurevich, Vsevolod V., et al.
Publicado: (2022)

Immunological Activity Difference between Native Calreticulin Monomers and Oligomers
por: He, Mi-chun, et al.
Publicado: (2014)

Allosteric modulation in monomers and oligomers of a G protein-coupled receptor
por: Shivnaraine, Rabindra V, et al.
Publicado: (2016)

Early stages of aggregation of engineered α-synuclein monomers and oligomers in solution
por: Li, Xi, et al.
Publicado: (2019)

The mechanism of monomer transfer between two structurally distinct PrP oligomers
por: Armiento, Aurora, et al.
Publicado: (2017)

Cooperative inhibition of SNARE-mediated vesicle fusion by α-synuclein monomers and oligomers
por: Yoo, Gyeongji, et al.
Publicado: (2021)

Circular RNAs of the nucleophosmin (NPM1) gene in acute myeloid leukemia
por: Hirsch, Susanne, et al.
Publicado: (2017)

Environmental Factors Preceding Aβ40 Monomer to Oligomers and the Detection of Oligomers in Alzheimer's Disease Patient Serum
por: Matsunaga, Yoichi, et al.
Publicado: (2012)

Distinct Internalization Pathways of Human Amylin Monomers and Its Cytotoxic Oligomers in Pancreatic Cells
por: Trikha, Saurabh, et al.
Publicado: (2013)

Toward Biorecycling: Isolation of a Soil Bacterium That Grows on a Polyurethane Oligomer and Monomer
por: Espinosa, María José Cárdenas, et al.
Publicado: (2020)

Probing protein aggregation at buried interfaces: distinguishing between adsorbed protein monomers, dimers, and a monomer–dimer mixture in situ
por: Lu, Tieyi, et al.
Publicado: (2021)

Biochemical and Bioinformatic Studies of Mutations of Residues at the Monomer–Monomer Interface of Human Ornithine Aminotransferase Leading to Gyrate Atrophy of Choroid and Retina
por: Floriani, Fulvio, et al.
Publicado: (2023)

Conformations of Islet Amyloid Polypeptide Monomers in a Membrane Environment: Implications for Fibril Formation
por: Duan, Mojie, et al.
Publicado: (2012)

Involvement of nucleophosmin (NPM1/B23) in assembly of infectious HPV16 capsids
por: Day, Patricia M., et al.
Publicado: (2015)

Nucleophosmin1 (NPM1) abnormality in hematologic malignancies, and therapeutic targeting of mutant NPM1 in acute myeloid leukemia
por: Chen, Yingyu, et al.
Publicado: (2020)

Expression of Nucleophosmin/NPM1 correlates with migration and invasiveness of colon cancer cells
por: Liu, Yan, et al.
Publicado: (2012)

The Multifunctional Nucleolar Protein Nucleophosmin/NPM/B23 and the Nucleoplasmin Family of Proteins
por: Yip, Shea Ping, et al.
Publicado: (2011)

The Role of Nucleophosmin 1 (NPM1) Mutation in the Diagnosis and Management of Myeloid Neoplasms
por: Kelemen, Katalin
Publicado: (2022)

Targeting and Monitoring Acute Myeloid Leukaemia with Nucleophosmin-1 (NPM1) Mutation
por: Chin, Lynn, et al.
Publicado: (2023)

Transient multimers modulate conformer abundances of prion protein monomer through conformational selection
por: Van der Rest, Guillaume, et al.
Publicado: (2019)

Aβ Peptide Fibrillar Architectures Controlled by Conformational Constraints of the Monomer
por: Brännström, Kristoffer, et al.
Publicado: (2011)

Folding Landscape of Mutant Huntingtin Exon1: Diffusible Multimers, Oligomers and Fibrils, and No Detectable Monomer
por: Sahoo, Bankanidhi, et al.
Publicado: (2016)

Endogenous alpha-synuclein monomers, oligomers and resulting pathology: let’s talk about the lipids in the room
por: Killinger, Bryan A., et al.
Publicado: (2019)

Functionalized Tobacco Mosaic Virus Coat Protein Monomers and Oligomers as Nanocarriers for Anti-Cancer Peptides
por: Gamper, Coralie, et al.
Publicado: (2019)

Controlling the Phase Behavior and Reflection of Main-Chain Cholesteric Oligomers Using a Smectic Monomer
por: Yue, Lansong, et al.
Publicado: (2022)

Oligomer-to-monomer transition underlies the chaperone function of AAGAB in AP1/AP2 assembly
por: Tian, Yuan, et al.
Publicado: (2023)

Brain Hydrophobic Peptides Antagonists of Neurotoxic Amyloid β Peptide Monomers/Oligomers–Protein Interactions
por: Gutierrez-Merino, Carlos
Publicado: (2023)

Allylic resins and monomers
por: Raech, Harry
Publicado: (1965)

New monomers and polymers
por: Culbertson, Bill, et al.
Publicado: (1984)

Bacterial initiators form dynamic filaments on single-stranded DNA monomer by monomer
por: Cheng, Hsin-Mei, et al.
Publicado: (2015)

Morphogenic Effects of Ezrin Require a Phosphorylation-Induced Transition from Oligomers to Monomers at the Plasma Membrane
por: Gautreau, Alexis, et al.
Publicado: (2000)

Thermodynamically stable amyloid-β monomers have much lower membrane affinity than the small oligomers
por: Sarkar, Bidyut, et al.
Publicado: (2013)

Synthesis of sequence-defined acrylate oligomers via photo-induced copper-mediated radical monomer insertions
por: Vandenbergh, Joke, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_r9ccm9fq5gpj222tq0ngtj1jj7