The T-box transcription factor Brachyury promotes renal interstitial fibrosis by repressing E-cadherin expression

BACKGROUND: Epithelial-to-mesenchymal transition (EMT) induced by TGF-β1 is one of well-recognized factors contributing to renal fibrosis. However, the underlying molecular mechanisms of EMT are not fully understood. Brachyury, an evolutionarily conserved transcription factor, was recently identifie...

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Detalles Bibliográficos
Autores principales: Sun, Shiren, Sun, Wenjuan, Xia, Lin, Liu, Limin, Du, Rui, He, Lijie, Li, Rong, Wang, Hanmin, Huang, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4261244/
https://www.ncbi.nlm.nih.gov/pubmed/25433496
http://dx.doi.org/10.1186/s12964-014-0076-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4261244/
https://www.ncbi.nlm.nih.gov/pubmed/25433496
http://dx.doi.org/10.1186/s12964-014-0076-4

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