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The T-box transcription factor Brachyury promotes renal interstitial fibrosis by repressing E-cadherin expression

BACKGROUND: Epithelial-to-mesenchymal transition (EMT) induced by TGF-β1 is one of well-recognized factors contributing to renal fibrosis. However, the underlying molecular mechanisms of EMT are not fully understood. Brachyury, an evolutionarily conserved transcription factor, was recently identifie...

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Detalles Bibliográficos
Autores principales:	Sun, Shiren, Sun, Wenjuan, Xia, Lin, Liu, Limin, Du, Rui, He, Lijie, Li, Rong, Wang, Hanmin, Huang, Chen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4261244/ https://www.ncbi.nlm.nih.gov/pubmed/25433496 http://dx.doi.org/10.1186/s12964-014-0076-4

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