PCI-24781 down-regulates EZH2 expression and then promotes glioma apoptosis by suppressing the PIK3K/Akt/mTOR pathway

PCI-24781 is a novel histone deacetylase inhibitor that inhibits tumor proliferation and promotes cell apoptosis. However, it is unclear whether PCI-24781 inhibits Enhancer of Zeste 2 (EZH2) expression in malignant gliomas. In this work, three glioma cell lines were incubated with various concentrat...

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Detalles Bibliográficos
Autores principales: Zhang, Wei, Lv, Shengqing, Liu, Jun, Zang, Zhenle, Yin, Junyi, An, Ning, Yang, Hui, Song, Yechun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Genética 2014
Materias:
Cellular, Molecular and Developmental Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4261972/
https://www.ncbi.nlm.nih.gov/pubmed/25505847
http://dx.doi.org/10.1590/S1415-47572014005000011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4261972/
https://www.ncbi.nlm.nih.gov/pubmed/25505847
http://dx.doi.org/10.1590/S1415-47572014005000011

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