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Multifunctional PEG Retinylamine Conjugate Provides Prolonged Protection against Retinal Degeneration in Mice
[Image: see text] A polyethylene glycol (PEG) retinylamine (Ret-NH(2)) conjugate PEG-GFL-NH-Ret with a glycine-phenylalanine-leucine (GFL) spacer was synthesized for controlled oral delivery of Ret-NH(2) to treat retinal degenerative diseases, including Stargardt disease (STGD) and age-related macul...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4261990/ https://www.ncbi.nlm.nih.gov/pubmed/25390360 http://dx.doi.org/10.1021/bm501352s |