Detection of the secondary, low-affinity β(1)-adrenoceptor site in living cells using the fluorescent CGP 12177 derivative BODIPY-TMR-CGP

BACKGROUND AND PURPOSE: CGP 12177 not only inhibits agonist effects mediated through the catecholamine site of the β(1)-adrenoceptor with high affinity, but also exhibits agonist effects of its own at higher concentrations through a secondary, low-affinity β(1)-adrenoceptor site or conformation. β-b...

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Detalles Bibliográficos
Autores principales: Gherbi, K, Briddon, S J, Hill, S J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4261997/
https://www.ncbi.nlm.nih.gov/pubmed/25052258
http://dx.doi.org/10.1111/bph.12858

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4261997/
https://www.ncbi.nlm.nih.gov/pubmed/25052258
http://dx.doi.org/10.1111/bph.12858

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