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Detection of the secondary, low-affinity β(1)-adrenoceptor site in living cells using the fluorescent CGP 12177 derivative BODIPY-TMR-CGP

BACKGROUND AND PURPOSE: CGP 12177 not only inhibits agonist effects mediated through the catecholamine site of the β(1)-adrenoceptor with high affinity, but also exhibits agonist effects of its own at higher concentrations through a secondary, low-affinity β(1)-adrenoceptor site or conformation. β-b...

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Detalles Bibliográficos
Autores principales:	Gherbi, K, Briddon, S J, Hill, S J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2014
Materias:	Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4261997/ https://www.ncbi.nlm.nih.gov/pubmed/25052258 http://dx.doi.org/10.1111/bph.12858

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