Intrinsic Thermodynamics and Structure Correlation of Benzenesulfonamides with a Pyrimidine Moiety Binding to Carbonic Anhydrases I, II, VII, XII, and XIII

The early stage of drug discovery is often based on selecting the highest affinity lead compound. To this end the structural and energetic characterization of the binding reaction is important. The binding energetics can be resolved into enthalpic and entropic contributions to the binding Gibbs free...

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Detalles Bibliográficos
Autores principales: Kišonaitė, Miglė, Zubrienė, Asta, Čapkauskaitė, Edita, Smirnov, Alexey, Smirnovienė, Joana, Kairys, Visvaldas, Michailovienė, Vilma, Manakova, Elena, Gražulis, Saulius, Matulis, Daumantas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262373/
https://www.ncbi.nlm.nih.gov/pubmed/25493428
http://dx.doi.org/10.1371/journal.pone.0114106

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262373/
https://www.ncbi.nlm.nih.gov/pubmed/25493428
http://dx.doi.org/10.1371/journal.pone.0114106

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