Functional characterization of a competitive peptide antagonist of p65 in human macrophage-like cells suggests therapeutic potential for chronic inflammation

Glucocorticoid-induced leucine zipper (GILZ) is a glucocorticoid responsive protein that links the nuclear factor-kappa B (NFκB) and the glucocorticoid signaling pathways. Functional and binding studies suggest that the proline-rich region at the carboxy terminus of GILZ binds the p65 subunit of NFκ...

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Detalles Bibliográficos
Autores principales: Srinivasan, Mythily, Blackburn, Corinne, Lahiri, Debomoy K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262379/
https://www.ncbi.nlm.nih.gov/pubmed/25584020
http://dx.doi.org/10.2147/DDDT.S59722

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262379/
https://www.ncbi.nlm.nih.gov/pubmed/25584020
http://dx.doi.org/10.2147/DDDT.S59722

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