Importance of Tryptophan in Transforming an Amphipathic Peptide into a Pseudomonas aeruginosa-Targeted Antimicrobial Peptide

Here, we found that simple substitution of amino acids in the middle position of the hydrophobic face of an amphipathic peptide RI16 with tryptophan (T9W) considerably transformed into an antimicrobial peptide specifically targeting Pseudomonas aeruginosa. Minimal inhibitory concentration (MIC) resu...

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Detalles Bibliográficos
Autores principales: Zhu, Xin, Ma, Zhi, Wang, Jiajun, Chou, Shuli, Shan, Anshan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262413/
https://www.ncbi.nlm.nih.gov/pubmed/25494332
http://dx.doi.org/10.1371/journal.pone.0114605

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262413/
https://www.ncbi.nlm.nih.gov/pubmed/25494332
http://dx.doi.org/10.1371/journal.pone.0114605

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