TDP-43 loss of cellular function through aggregation requires additional structural determinants beyond its C-terminal Q/N prion-like domain

TDP-43 aggregates are the neurohistological landmark of diseases like amyotrophic lateral sclerosis and frontotemporal dementia. Their role in the pathogenesis of these conditions is not yet clear mainly due to the lack of proper models of aggregation that may allow the study of the mechanism of for...

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Detalles Bibliográficos
Autores principales: Budini, Mauricio, Romano, Valentina, Quadri, Zainuddin, Buratti, Emanuele, Baralle, Francisco E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262490/
https://www.ncbi.nlm.nih.gov/pubmed/25122661
http://dx.doi.org/10.1093/hmg/ddu415

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262490/
https://www.ncbi.nlm.nih.gov/pubmed/25122661
http://dx.doi.org/10.1093/hmg/ddu415

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