Synergic prodegradative activity of Bicalutamide and trehalose on the mutant androgen receptor responsible for spinal and bulbar muscular atrophy

Spinal and bulbar muscular atrophy (SBMA) is an X-linked motoneuron disease due to a CAG triplet-repeat expansion in the androgen receptor (AR) gene, which is translated into an elongated polyglutamine (polyQ) tract in AR protein (ARpolyQ). ARpolyQ toxicity is activated by the AR ligand testosterone...

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Detalles Bibliográficos
Autores principales: Giorgetti, Elisa, Rusmini, Paola, Crippa, Valeria, Cristofani, Riccardo, Boncoraglio, Alessandra, Cicardi, Maria E., Galbiati, Mariarita, Poletti, Angelo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262493/
https://www.ncbi.nlm.nih.gov/pubmed/25122660
http://dx.doi.org/10.1093/hmg/ddu419

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262493/
https://www.ncbi.nlm.nih.gov/pubmed/25122660
http://dx.doi.org/10.1093/hmg/ddu419

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