Cargando…

Synergic prodegradative activity of Bicalutamide and trehalose on the mutant androgen receptor responsible for spinal and bulbar muscular atrophy

Spinal and bulbar muscular atrophy (SBMA) is an X-linked motoneuron disease due to a CAG triplet-repeat expansion in the androgen receptor (AR) gene, which is translated into an elongated polyglutamine (polyQ) tract in AR protein (ARpolyQ). ARpolyQ toxicity is activated by the AR ligand testosterone...

Descripción completa

Detalles Bibliográficos
Autores principales:	Giorgetti, Elisa, Rusmini, Paola, Crippa, Valeria, Cristofani, Riccardo, Boncoraglio, Alessandra, Cicardi, Maria E., Galbiati, Mariarita, Poletti, Angelo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262493/ https://www.ncbi.nlm.nih.gov/pubmed/25122660 http://dx.doi.org/10.1093/hmg/ddu419

Ejemplares similares

Bicalutamide and Trehalose Ameliorate Spinal and Bulbar Muscular Atrophy Pathology in Mice
por: Galbiati, Mariarita, et al.
Publicado: (2023)

Clearance of the mutant androgen receptor in motoneuronal models of spinal and bulbar muscular atrophy()
por: Rusmini, Paola, et al.
Publicado: (2013)

Autophagic and Proteasomal Mediated Removal of Mutant Androgen Receptor in Muscle Models of Spinal and Bulbar Muscular Atrophy
por: Cicardi, Maria Elena, et al.
Publicado: (2019)

Aberrant Autophagic Response in The Muscle of A Knock-in Mouse Model of Spinal and Bulbar Muscular Atrophy
por: Rusmini, Paola, et al.
Publicado: (2015)

The role of dynein mediated transport in the clearance of misfolded proteins responsible for motoneuron diseases
por: Cristofani, Riccardo, et al.
Publicado: (2015)

Differential autophagy power in the spinal cord and muscle of transgenic ALS mice
por: Crippa, Valeria, et al.
Publicado: (2013)

Androgens in spinal and bulbar muscular atrophy
Publicado: (2012)

Tdp-25 Routing to Autophagy and Proteasome Ameliorates its Aggregation in Amyotrophic Lateral Sclerosis Target Cells
por: Cicardi, Maria Elena, et al.
Publicado: (2018)

Human Adipose-Derived Mesenchymal Stem Cells as a New Model of Spinal and Bulbar Muscular Atrophy
por: Dossena, Marta, et al.
Publicado: (2014)

Alteration of the protein quality control system in motor neuron and muscle expressing mutant proteins causing ALS and SBMA
por: Cicardi, Maria Elena, et al.
Publicado: (2015)

A Crucial Role for the Protein Quality Control System in Motor Neuron Diseases
por: Cristofani, Riccardo, et al.
Publicado: (2020)

Inhibition of retrograde transport modulates misfolded protein accumulation and clearance in motoneuron diseases
por: Cristofani, Riccardo, et al.
Publicado: (2017)

The protein quality control system in motoneuron diseases
por: Poletti, Angelo, et al.
Publicado: (2015)

The small heat shock protein B8 (HSPB8) modulates proliferation and migration of breast cancer cells
por: Piccolella, Margherita, et al.
Publicado: (2017)

The small heat shock protein B8 (HSPB8) efficiently removes aggregating species of dipeptides produced in C9ORF72-related neurodegenerative diseases
por: Cristofani, Riccardo, et al.
Publicado: (2017)

The Regulation of the Small Heat Shock Protein B8 in Misfolding Protein Diseases Causing Motoneuronal and Muscle Cell Death
por: Cristofani, Riccardo, et al.
Publicado: (2019)

The Role of the Heat Shock Protein B8 (HSPB8) in Motoneuron Diseases
por: Rusmini, Paola, et al.
Publicado: (2017)

Impaired Nuclear Export of Polyglutamine-Expanded Androgen Receptor in Spinal and Bulbar Muscular Atrophy
por: Arnold, Frederick J., et al.
Publicado: (2019)

The anabolic/androgenic steroid nandrolone exacerbates gene expression modifications induced by mutant SOD1 in muscles of mice models of amyotrophic lateral sclerosis
por: Galbiati, Mariarita, et al.
Publicado: (2012)

Enhanced Clearance of Neurotoxic Misfolded Proteins by the Natural Compound Berberine and Its Derivatives
por: Rusmini, Paola, et al.
Publicado: (2020)

Mitochondrial abnormalities in spinal and bulbar muscular atrophy
por: Ranganathan, Srikanth, et al.
Publicado: (2009)

Clinical features of spinal and bulbar muscular atrophy
por: Rhodes, Lindsay E., et al.
Publicado: (2009)

Swallowing markers in spinal and bulbar muscular atrophy
por: Banno, Haruhiko, et al.
Publicado: (2017)

The role of ubiquitination in spinal and bulbar muscular atrophy
por: Sengupta, Medha, et al.
Publicado: (2022)

MiR-298 Counteracts Mutant Androgen Receptor Toxicity in Spinal and Bulbar Muscular Atrophy
por: Pourshafie, Naemeh, et al.
Publicado: (2016)

Multiple Roles of Transforming Growth Factor Beta in Amyotrophic Lateral Sclerosis
por: Galbiati, Mariarita, et al.
Publicado: (2020)

Mechanisms Mediating Spinal and Bulbar Muscular Atrophy: Investigations into Polyglutamine-Expanded Androgen Receptor Function and Dysfunction
por: Beitel, Lenore K., et al.
Publicado: (2013)

Mid1 is associated with androgen-dependent axonal vulnerability of motor neurons in spinal and bulbar muscular atrophy
por: Ogura, Yosuke, et al.
Publicado: (2022)

Neuropathology and Therapeutic Intervention in Spinal and Bulbar Muscular Atrophy
por: Banno, Haruhiko, et al.
Publicado: (2009)

Current Status of Treatment of Spinal and Bulbar Muscular Atrophy
por: Tanaka, Fumiaki, et al.
Publicado: (2012)

Clinical Phenotyping and Biomarkers in Spinal and Bulbar Muscular Atrophy
por: Millere, Elina, et al.
Publicado: (2021)

Transcriptional induction of the heat shock protein B8 mediates the clearance of misfolded proteins responsible for motor neuron diseases
por: Crippa, Valeria, et al.
Publicado: (2016)

Muscle cells and motoneurons differentially remove mutant SOD1 causing familial amyotrophic lateral sclerosis
por: Onesto, Elisa, et al.
Publicado: (2011)

Retinoic Acid Downregulates HSPB8 Gene Expression in Human Breast Cancer Cells MCF-7
por: Piccolella, Margherita, et al.
Publicado: (2021)

Valosin Containing Protein (VCP): A Multistep Regulator of Autophagy
por: Ferrari, Veronica, et al.
Publicado: (2022)

The Role of Small Heat Shock Proteins in Protein Misfolding Associated Motoneuron Diseases
por: Tedesco, Barbara, et al.
Publicado: (2022)

Selective Modulation of the Androgen Receptor Activation Function-2 Domain Rescues Degeneration in Spinal Bulbar Muscular Atrophy
por: Badders, Nisha M, et al.
Publicado: (2018)

Correlation of clinical and molecular features in spinal bulbar muscular atrophy
por: Fratta, Pietro, et al.
Publicado: (2014)

Impaired muscle uptake of creatine in spinal and bulbar muscular atrophy
por: Hijikata, Yasuhiro, et al.
Publicado: (2016)

Patient‐identified impact of symptoms in spinal and bulbar muscular atrophy
por: Guber, Robert D., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_oj8te3o19q5hvj3al8kp98s6mv