Epigenetic memory of the first cell fate decision prevents complete ES cell reprogramming into trophoblast

Embryonic (ES) and trophoblast (TS) stem cells reflect the first, irrevocable cell fate decision in development that is reinforced by distinct epigenetic lineage barriers. Nonetheless, ES cells can seemingly acquire TS-like characteristics upon manipulation of lineage-determining transcription facto...

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Detalles Bibliográficos
Autores principales: Cambuli, Francesco, Murray, Alexander, Dean, Wendy, Dudzinska, Dominika, Krueger, Felix, Andrews, Simon, Senner, Claire E., Cook, Simon J., Hemberger, Myriam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263130/
https://www.ncbi.nlm.nih.gov/pubmed/25423963
http://dx.doi.org/10.1038/ncomms6538

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263130/
https://www.ncbi.nlm.nih.gov/pubmed/25423963
http://dx.doi.org/10.1038/ncomms6538

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