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Epigenetic memory of the first cell fate decision prevents complete ES cell reprogramming into trophoblast
Embryonic (ES) and trophoblast (TS) stem cells reflect the first, irrevocable cell fate decision in development that is reinforced by distinct epigenetic lineage barriers. Nonetheless, ES cells can seemingly acquire TS-like characteristics upon manipulation of lineage-determining transcription facto...
Autores principales: | Cambuli, Francesco, Murray, Alexander, Dean, Wendy, Dudzinska, Dominika, Krueger, Felix, Andrews, Simon, Senner, Claire E., Cook, Simon J., Hemberger, Myriam |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Pub. Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263130/ https://www.ncbi.nlm.nih.gov/pubmed/25423963 http://dx.doi.org/10.1038/ncomms6538 |
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