The immunoglobulin tail tyrosine motif upgrades memory-type BCRs by incorporating a Grb2-Btk signalling module

The vigorous response of IgG-switched memory B cells to recurring pathogens involves enhanced signalling from their B-cell antigen receptors (BCRs). However, the molecular signal amplification mechanisms of memory-type BCRs remained unclear. Here, we identify the immunoglobulin tail tyrosine (ITT) m...

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Detalles Bibliográficos
Autores principales: Engels, Niklas, König, Lars M., Schulze, Wiebke, Radtke, Daniel, Vanshylla, Kanika, Lutz, Johannes, Winkler, Thomas H., Nitschke, Lars, Wienands, Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263166/
https://www.ncbi.nlm.nih.gov/pubmed/25413232
http://dx.doi.org/10.1038/ncomms6456

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263166/
https://www.ncbi.nlm.nih.gov/pubmed/25413232
http://dx.doi.org/10.1038/ncomms6456

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