Double-sieving-defective aminoacyl-tRNA synthetase causes protein mistranslation and affects cellular physiology and development

Aminoacyl-tRNA synthetases (aaRSs) constitute a family of ubiquitously expressed essential enzymes that ligate amino acids to their cognate tRNAs for protein synthesis. Recently, aaRS mutations have been linked to various human diseases; however, how these mutations lead to diseases has remained unc...

Descripción completa

Detalles Bibliográficos
Autores principales: Lu, Jiongming, Bergert, Martin, Walther, Anita, Suter, Beat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263187/
https://www.ncbi.nlm.nih.gov/pubmed/25427601
http://dx.doi.org/10.1038/ncomms6650

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263187/
https://www.ncbi.nlm.nih.gov/pubmed/25427601
http://dx.doi.org/10.1038/ncomms6650

Ejemplares similares