Understanding the Relationship Between Biotherapeutic Protein Stability and Solid–Liquid Interfacial Shear in Constant Region Mutants of IgG1 and IgG4

Relative stability of therapeutic antibody candidates is currently evaluated primarily through their response to thermal degradation, yet this technique is not always predictive of stability in manufacture, shipping, and storage. A rotating disk shear device is proposed that produces defined shear c...

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Detalles Bibliográficos
Autores principales: Tavakoli-Keshe, Roumteen, Phillips, Jonathan J, Turner, Richard, Bracewell, Daniel G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Pharmaceutical Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263191/
https://www.ncbi.nlm.nih.gov/pubmed/24357426
http://dx.doi.org/10.1002/jps.23822

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263191/
https://www.ncbi.nlm.nih.gov/pubmed/24357426
http://dx.doi.org/10.1002/jps.23822

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