Cargando…

Modifying Caspase-3 Activity by Altering Allosteric Networks

[Image: see text] Caspases have several allosteric sites that bind small molecules or peptides. Allosteric regulators are known to affect caspase enzyme activity, in general, by facilitating large conformational changes that convert the active enzyme to a zymogen-like form in which the substrate-bin...

Descripción completa

Detalles Bibliográficos
Autores principales: Cade, Christine, Swartz, Paul, MacKenzie, Sarah H., Clark, A. Clay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263430/
https://www.ncbi.nlm.nih.gov/pubmed/25343534
http://dx.doi.org/10.1021/bi500874k