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Electrostatic Properties of Complexes along a DNA Glycosylase Damage Search Pathway

[Image: see text] Human uracil DNA glycosylase (hUNG) follows an extended reaction coordinate for locating rare uracil bases in genomic DNA. This process begins with diffusion-controlled engagement of undamaged DNA, followed by a damage search step in which the enzyme remains loosely associated with...

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Detalles Bibliográficos
Autores principales: Cravens, Shannen L., Hobson, Matthew, Stivers, James T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263432/
https://www.ncbi.nlm.nih.gov/pubmed/25408964
http://dx.doi.org/10.1021/bi501011m