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Formation of α-synuclein Lewy neurite–like aggregates in axons impedes the transport of distinct endosomes
Aggregates of α-synuclein (α-syn) accumulate in neurons in Parkinson's disease and other synucleinopathies. These inclusions predominantly localize to axons even in the early stages of the disease, but their affect on axon function has remained unknown. Previously we established a model in whic...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The American Society for Cell Biology
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263445/ https://www.ncbi.nlm.nih.gov/pubmed/25298402 http://dx.doi.org/10.1091/mbc.E14-02-0741 |