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Formation of α-synuclein Lewy neurite–like aggregates in axons impedes the transport of distinct endosomes

Aggregates of α-synuclein (α-syn) accumulate in neurons in Parkinson's disease and other synucleinopathies. These inclusions predominantly localize to axons even in the early stages of the disease, but their affect on axon function has remained unknown. Previously we established a model in whic...

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Detalles Bibliográficos
Autores principales:	Volpicelli-Daley, Laura A., Gamble, Karen L., Schultheiss, Christine E., Riddle, Dawn M., West, Andrew B., Lee, Virginia M.-Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2014
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263445/ https://www.ncbi.nlm.nih.gov/pubmed/25298402 http://dx.doi.org/10.1091/mbc.E14-02-0741

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