Development of a Fish Cell Biosensor System for Genotoxicity Detection Based on DNA Damage-Induced Trans-Activation of p21 Gene Expression

p21(CIP1/WAF1) is a p53-target gene in response to cellular DNA damage. Here we report the development of a fish cell biosensor system for high throughput genotoxicity detection of new drugs, by stably integrating two reporter plasmids of pGL(3)-p21-luc (human p21 promoter linked to firefly lucifera...

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Detalles Bibliográficos
Autores principales: Geng, Deyu, Zhang, Zhixia, Guo, Huarong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263550/
https://www.ncbi.nlm.nih.gov/pubmed/25585933
http://dx.doi.org/10.3390/bios2030318

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263550/
https://www.ncbi.nlm.nih.gov/pubmed/25585933
http://dx.doi.org/10.3390/bios2030318

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